{"title":"PDRN","description":"\u003cp\u003ePDRN (polydeoxyribonucleotide, often derived from salmon) breaks down into adenosine and activates repair and regeneration mechanisms documented in laboratory studies. The strongest clinical evidence concerns the injectable version; for topical cosmetic use, independent studies remain limited — a distinction we prefer to state clearly rather than leave implied by marketing. A trending K-beauty active in 2026, often paired with exosomes or collagen in recent formulas.\u003c\/p\u003e\n\u003ch2\u003eHow to choose\u003c\/h2\u003e\n\u003cp\u003eAs a first contact, a PDRN toner pad or mist slots into the routine morning and evening without changing anything else. For a richer comfort step, PDRN creams paired with panthenol and centella suit weakened skin. As a weekly ritual, night masks and \"glaze\" masks deliver the most visible glow on waking. Be wary of spectacular percentages: a \"99% PDRN\" may correspond to a few ppm in the INCI list. No major contraindication has been identified for topical use; the active combines with niacinamide, peptides and hyaluronic acid.\u003c\/p\u003e\n\u003ch2\u003ePair it with\u003c\/h2\u003e\n\u003cp\u003eBrowse our \u003ca href=\"\/en-gb\/collections\/collagene\"\u003ecollagen\u003c\/a\u003e products, the PDRN Pink range from \u003ca href=\"\/en-gb\/collections\/marque-medicube\"\u003eMedicube\u003c\/a\u003e and our \u003ca href=\"\/en-gb\/collections\/signes-de-lage\"\u003esigns of aging\u003c\/a\u003e selection for actives backed by stronger evidence.\u003c\/p\u003e","products":[{"product_id":"dr-althea-reju-5000-cream","title":"Dr.Althea Reju 5000 Cream, 20 g","description":"\u003cp\u003eA light gel-cream that melts instantly without leaving a film, carried by 50,000 ppm panthenol and 50,000 ppm centella leaf water that seal the texture in with an immediate feeling of comfort.\u003c\/p\u003e\n\u003ch2\u003eWhy we love it\u003c\/h2\u003e\n\u003cp\u003ePDRN (purified salmon DNA, here as sodium DNA at 5,000 ppm) activates the A2A receptor involved in cell repair and collagen production. Its strongest evidence concerns the injectable route, used in professional dermatology; for topical application, only one clinical study (2025, periorbital elasticity) exists to date — the two routes are not equivalent, and topical use remains a comfort treatment rather than a proven medical protocol. Sh-oligopeptide-1, a biotech analog of EGF, adds to the effect on perceived firmness. This formula extends Dr.Althea's retinol range, a Korean brand built on minimalist formulas designed for reactive skin seeking a regenerating treatment without an excess of active ingredients.\u003c\/p\u003e\n\u003ch2\u003eHow to use it\u003c\/h2\u003e\n\u003cp\u003eMorning and\/or evening, on cleansed skin, a hazelnut-sized amount patted in until fully absorbed, as the last step or before a richer cream. Combines without precaution with niacinamide, peptides and hyaluronic acid, and suits recovery evenings after retinol.\u003c\/p\u003e\n\u003ch2\u003eWho it's for\u003c\/h2\u003e\n\u003cp\u003eSuitable for sensitive skin in a daily routine, for weakened or dehydrated skin looking for comfort, and for anyone who wants to discover PDRN in a lightweight texture. Also discover our \u003ca href=\"\/en-gb\/collections\/pdrn\"\u003ePDRN\u003c\/a\u003e selection and our \u003ca href=\"\/en-gb\/collections\/signes-de-lage\"\u003esigns of aging\u003c\/a\u003e products.\u003c\/p\u003e","brand":"Dr.Althea","offers":[{"title":"Default Title","offer_id":53801707569418,"sku":"DRALTHEA-REJU5000","price":29.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0965\/7152\/3338\/files\/dralthea-reju-5000-cream.jpg?v=1790197001"},{"product_id":"medicube-pdrn-pink-caffeine-night-wrapping-mask-75ml","title":"Medicube PDRN Pink Caffeine Night Wrapping Mask 75ml","description":"\u003cp\u003eA shimmering pink gel that settles like a glossy second skin, for an immediate feeling of comfort and radiance upon waking.\u003c\/p\u003e\n\u003ch2\u003eWhy we love it\u003c\/h2\u003e\n\u003cp\u003eCombines \u003ca href=\"\/en-gb\/collections\/pdrn\"\u003ePDRN\u003c\/a\u003e (salmon DNA) with caffeine: the strongest evidence on PDRN mainly concerns the injectable route, while the topical version still has limited but promising data on elasticity; caffeine, meanwhile, is recognized for its decongestant effect that visibly refines features upon waking. As no PDRN percentage is printed on the packaging, we quote no figure: the effect described is that of a hydrating film and a rested complexion, not a regeneration protocol. A treatment that has joined Medicube's must-haves, riding the wave of PDRN, one of the most sought-after K-beauty actives of the past two years.\u003c\/p\u003e\n\u003ch2\u003eHow to use it\u003c\/h2\u003e\n\u003cp\u003e3 to 4 times a week in the evening, on cleansed skin, apply a thin layer and leave on overnight, then peel off or rinse with lukewarm water upon waking. Can be applied after a hydrating serum; avoid combining it on the same evening with retinol or an acid exfoliant.\u003c\/p\u003e\n\u003ch2\u003eWho it's for\u003c\/h2\u003e\n\u003cp\u003eTired, dull or puffy skin on waking, dehydrated skin that wants a lightweight night treatment, and anyone who wants to discover PDRN in a feel-good format. Suitable for sensitive skin; no major contraindication identified for topical use. Discover our other \u003ca href=\"\/en-gb\/collections\/masques\"\u003eKorean masks\u003c\/a\u003e.\u003c\/p\u003e","brand":"Medicube","offers":[{"title":"Default Title","offer_id":53801716384010,"sku":"MEDICUBE-PDRNWRAP","price":29.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0965\/7152\/3338\/files\/02-pdrn-pink-caffeine-wrapping-mask.jpg?v=1790197127"},{"product_id":"cosrx-pdrn-exosome-skinplaning-glaze-mask-50ml","title":"COSRX PDRN Exosome Skinplaning Glaze Mask 50ml","description":"\u003cp\u003eA cream mask applied in a single layer that turns into a satin film, for an immediate \"glazed skin\" effect once peeled off.\u003c\/p\u003e\n\u003ch2\u003eWhy we love it\u003c\/h2\u003e\n\u003cp\u003eFormulated with \u003ca href=\"\/en-gb\/collections\/pdrn\"\u003ePDRN\u003c\/a\u003e and exosomes, two trending actives whose scientific basis is real but still young when it comes to topical application: PDRN is broken down into adenosine and is thought to activate skin repair mechanisms, but the strongest clinical evidence today concerns injectable PDRN — use in a mask remains more of a feel-good treatment than an established clinical protocol. No PDRN or exosome percentage is disclosed by the brand for this product, so we describe the effect as it is: gentle surface exfoliation combined with on-trend regenerating actives. A silicone brush is included for clean, hands-free application — the gesture that made this format a hit on Korean social media.\u003c\/p\u003e\n\u003ch2\u003eHow to use it\u003c\/h2\u003e\n\u003cp\u003eAs an occasional treatment, 1 to 2 times a week: apply a generous layer on cleansed skin with the brush provided, leave on for 15 to 20 minutes, remove the film then massage in the residue to help absorption. Avoid the immediate eye contour and do not pair the mask with retinol or an acid exfoliant on the same evening.\u003c\/p\u003e\n\u003ch2\u003eWho it's for\u003c\/h2\u003e\n\u003cp\u003eDull skin or skin with uneven texture looking for an immediate \"glass skin\" effect, dehydrated skin, and anyone who wants to discover PDRN in a playful format. Suitable for sensitive skin; avoid on damaged skin. Find our other \u003ca href=\"\/en-gb\/collections\/masques\"\u003eKorean masks\u003c\/a\u003e.\u003c\/p\u003e","brand":"COSRX","offers":[{"title":"Default Title","offer_id":53801749020938,"sku":"COSRX-PDRNMASK","price":22.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0965\/7152\/3338\/files\/cosrx-pdrn-exosome-mask.jpg?v=1790197346"},{"product_id":"mary-may-spicule-collagen-pdrn-cream-15g","title":"Mary\u0026May Spicule Collagen PDRN Cream 15g","description":"\u003cp\u003eA rich, melting cream powered by over 90,000 marine micro-spicules (1,000 ppm), structures as fine as a needle and 40 times smaller than a pore: they create temporary micro-channels to help prepare the skin to better receive the actives that follow, without the sensations of a microneedling session.\u003c\/p\u003e\n\u003ch2\u003eWhy we love it\u003c\/h2\u003e\n\u003cp\u003eThe CICA PDRN complex and French marine collagen (3,000 ppm) aim to support skin firmness and hydration. Note: the strongest clinical data on PDRN concerns its injectable form; in a topical application like this one, published research is still limited, which doesn't stop the formula from being designed for compromised skin, with 2% panthenol, ceramide NP, and hyaluronic acid. Mary\u0026amp;May cites internal tests on skin firmness and elasticity; we have not identified an independent published study to date, so we prefer to tell you this rather than wave around an unverifiable figure.\u003c\/p\u003e\n\u003ch2\u003eHow to use it\u003c\/h2\u003e\n\u003cp\u003ePreferably in the evening, on cleansed skin: take a hazelnut-sized amount and massage until absorbed, as the last step of the routine or before night cream. A slight tingling from the spicules is normal for the first few minutes; start with two to three evenings a week, with no exfoliant or retinol on the same evening, and avoid any damaged skin.\u003c\/p\u003e\n\u003ch2\u003eWho it's for\u003c\/h2\u003e\n\u003cp\u003eMature or weakened skin looking for firmness and comfort, dehydrated skin, and anyone curious about spicule technology in a gentle version. For intact skin only; very reactive skin should test on a small area first. Ideal alongside a \u003ca href=\"\/en-gb\/collections\/pdrn\"\u003ePDRN\u003c\/a\u003e treatment and our \u003ca href=\"\/en-gb\/collections\/collagene\"\u003ecollagen\u003c\/a\u003e products.\u003c\/p\u003e","brand":"Mary\u0026May","offers":[{"title":"15 g","offer_id":53801757212938,"sku":"MARYMAY-COLLAGENPDRN-15","price":9.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0965\/7152\/3338\/files\/mary-may-spicule-collagen-pdrn-cream-15g.jpg?v=1790197361"},{"product_id":"mary-may-spicule-retinol-pdrn-cream-15g","title":"Mary\u0026May Spicule Retinol PDRN Cream 15g","description":"\u003cp\u003eThe same marine micro-spicule technology, here doubled (2,000 ppm, i.e. roughly 180,000 to 200,000 spicules per tube) and paired with a nano-liposomal retinol at 1,000 ppm: a texture that melts without any grain, designed to limit the usual discomfort of retinol.\u003c\/p\u003e\n\u003ch2\u003eWhy we love it\u003c\/h2\u003e\n\u003cp\u003eNano-encapsulation aims to improve the stability and absorption of retinol while reducing its irritation potential; the CICA PDRN complex and 2% panthenol support the skin during the adjustment period. Retinol remains a demanding active: it should be avoided during pregnancy and breastfeeding, never combined with AHAs\/BHAs or pure vitamin C on the same evening, and it requires sun protection the following morning. Mary\u0026amp;May reports internal results on pores, fine lines, and firmness; in the absence of an independent published study we could verify, we describe here what the formula does rather than a brand-supplied figure.\u003c\/p\u003e\n\u003ch2\u003eHow to use it\u003c\/h2\u003e\n\u003cp\u003eUse only in the evening, 2 to 3 times a week at first, then daily if your skin tolerates it: apply a hazelnut-sized amount on dry skin, as the last step before night cream, never on damp skin or combined with an exfoliant the same evening. Sun protection is mandatory the following morning. The tingling of the spicules adds to that of the retinol: space out applications if the skin reddens.\u003c\/p\u003e\n\u003ch2\u003eWho it's for\u003c\/h2\u003e\n\u003cp\u003eSkin already used to retinol that wants to go further on pores and fine lines, mature skin with uneven texture, excluding pregnancy and breastfeeding. Beginners should start with a spicule-free retinol cream. A companion to our \u003ca href=\"\/en-gb\/collections\/retinol\"\u003eRetinol\u003c\/a\u003e range and our \u003ca href=\"\/en-gb\/collections\/pdrn\"\u003ePDRN\u003c\/a\u003e products.\u003c\/p\u003e","brand":"Mary\u0026May","offers":[{"title":"15 g","offer_id":53801757409546,"sku":"MARYMAY-RETINOLPDRN-15","price":9.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0965\/7152\/3338\/files\/mary-may-spicule-retinol-pdrn-cream-15g.jpg?v=1790197361"},{"product_id":"medicube-pdrn-pink-exosome-shot-serum-2000","title":"Medicube PDRN Pink Exosome Shot Serum 2000, 30 ml","description":"\u003cp\u003eA liquid booster with a pink finish, in a fluid texture that absorbs quickly and prepares the skin to better receive the rest of the routine. The 2000 format, the gentlest in the range, is a popular entry point for discovering Medicube's PDRN products.\u003c\/p\u003e\n\u003ch2\u003eWhy we love it\u003c\/h2\u003e\n\u003cp\u003eBased on \u003ca href=\"\/en-gb\/collections\/pdrn\"\u003ePDRN\u003c\/a\u003e (salmon DNA), collagen and plant-derived exosomes, in a hydrating base. What the science says: PDRN is mostly documented by injection, where it acts on tissue repair; for topical use, clinical evidence remains limited, and the two routes are not equivalent. We therefore present it for what it really brings: immediate comfort, light hydration and a fresh glow that have made this active one of the most sought-after in K-beauty. Its watery texture does not stick and layers with everything.\u003c\/p\u003e\n\u003ch2\u003eHow to use it\u003c\/h2\u003e\n\u003cp\u003eAs the first step of the routine, on cleansed skin, morning and\/or evening: a few drops pressed in with the fingertips until fully absorbed, then toner or straight to serum. Can also be used after the toner as a hydrating booster. Compatible with all actives, including retinol and vitamin C.\u003c\/p\u003e\n\u003ch2\u003eWho it is for\u003c\/h2\u003e\n\u003cp\u003eDull, dehydrated or tired skin, normal to combination skin, and anyone curious to discover PDRN before moving on to more concentrated \u003ca href=\"\/en-gb\/collections\/serums-ampoules\"\u003eKorean serums\u003c\/a\u003e. Suits sensitive skin.\u003c\/p\u003e","brand":"Medicube","offers":[{"title":"Default Title","offer_id":53801816195338,"sku":"MEDICUBE-PDRNEXOSOME2000","price":26.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0965\/7152\/3338\/files\/medicube-pdrn-pink-exosome-shot-serum-2000.jpg?v=1790197674"},{"product_id":"medicube-pdrn-pink-glutathione-serum-mist","title":"Medicube PDRN Pink Glutathione Serum Mist, 100 ml","description":"\u003cp\u003eA two-texture serum mist that instantly refreshes the face while leaving a silky, non-sticky finish. A mist format that became a cult favourite at Medicube for the immediate freshness it brings.\u003c\/p\u003e\n\u003ch2\u003eWhy we love it\u003c\/h2\u003e\n\u003cp\u003eIt pairs \u003ca href=\"\/en-gb\/collections\/pdrn\"\u003ePDRN\u003c\/a\u003e with glutathione, an antioxidant recognised for fighting oxidative stress, in a two-phase formula to shake that blends a watery phase and a hydrating phase. What the science says: as with all PDRN products, the solid evidence mainly concerns the injectable route, topical use resting on still-limited literature; topical glutathione has a surface antioxidant action. A comfort and glow product, to be taken for what it is: a mist that hydrates, refreshes and revives a \u003ca href=\"\/en-gb\/collections\/taches-teint-terne\"\u003edull complexion\u003c\/a\u003e in one gesture, without disturbing makeup.\u003c\/p\u003e\n\u003ch2\u003eHow to use it\u003c\/h2\u003e\n\u003cp\u003eShake, then spray 20-30 cm from the face with eyes closed, on bare skin after cleansing or over makeup, as often as needed during the day. Pat lightly to help absorption. Can replace the toner in the morning or serve as daytime rehydration, at the office or when travelling. Compatible with all actives.\u003c\/p\u003e\n\u003ch2\u003eWho it is for\u003c\/h2\u003e\n\u003cp\u003eDull, dehydrated skin or skin that feels tight during the day, combination skin seeking light hydration, and all skin types looking for a refreshing gesture. Suits sensitive skin.\u003c\/p\u003e","brand":"Medicube","offers":[{"title":"Default Title","offer_id":53801816621322,"sku":"MEDICUBE-PDRNGLUTATHIONE","price":26.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0965\/7152\/3338\/files\/medicube-pdrn-pink-glutathione-serum-mist.jpg?v=1790197674"},{"product_id":"medicube-pdrn-pink-collagen-toning-gel-toner-pad","title":"Medicube PDRN Pink Collagen Toning Gel Toner Pad, 70 pads","description":"\u003cp\u003eA bouncy gel pad that turns into a soft texture on contact with the skin, for a toning gesture that is both exfoliating and plumping.\u003c\/p\u003e\n\u003ch2\u003eWhy we love it\u003c\/h2\u003e\n\u003cp\u003eEnriched with PDRN and low-molecular-weight \u003ca href=\"\/en-gb\/collections\/collagene\"\u003ecollagen\u003c\/a\u003e: collagen mainly acts as a surface film former, temporarily smoothing the look of the skin, while PDRN, as with the whole range, remains better documented via the injectable route than topically. A duo designed for comfort and complexion radiance, with no strong acid: the \"exfoliating\" effect comes from the gel texture that gently lifts dead surface cells. The gel-pad format, a signature of the PDRN Pink line, has made it one of the brand's most shared toning treatments.\u003c\/p\u003e\n\u003ch2\u003eHow to use it\u003c\/h2\u003e\n\u003cp\u003eAfter cleansing, let the pad sit in its essence for 5 seconds before applying; pat over the whole face or leave on for 5 minutes as a targeted mask, morning and\/or evening, then follow with serum. The ingredient list published by European retailers also mentions a small amount of retinol and a salicylic acid derivative: wear sunscreen during the day, avoid combining it on the same evening with another exfoliant or a retinoid, and ask a healthcare professional during pregnancy or breastfeeding.\u003c\/p\u003e\n\u003ch2\u003eWho it's for\u003c\/h2\u003e\n\u003cp\u003eDull or dehydrated skin looking for a plumping toner, sensitive skin that prefers a gentle pad, introduced gradually, and anyone who wants to discover PDRN in a simple daily step. Find our other \u003ca href=\"\/en-gb\/collections\/pdrn\"\u003ePDRN\u003c\/a\u003e products.\u003c\/p\u003e","brand":"Medicube","offers":[{"title":"Default Title","offer_id":53801816654090,"sku":"MEDICUBE-PDRNCOLLAGENPAD","price":28.9,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0965\/7152\/3338\/files\/medicube-pdrn-pink-collagen-toning-gel-toner-pad.jpg?v=1790197674"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0965\/7152\/3338\/collections\/collection-pdrn.jpg?v=1790280618","url":"https:\/\/glasskin-beauty.com\/en-gb\/collections\/pdrn.oembed","provider":"Glasskin Beauty","version":"1.0","type":"link"}